Cell Chemical Biology · Scour

Visualization of calpain-1 activation during cell death and its role in GSDMD cleavage using chemical probes

Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation

Understanding, inhibiting, and engineering membrane transporters with high-throughput mutational screens

Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets

CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers

Targeted degradation of CDK9 potently disrupts the MYC-regulated network

Dynamic PRDX S-acylation modulates ROS stress and signaling

Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator

An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology

NAPE-PLD is target of thiazide diuretics

De novo designed Hsp70 activator dissolves intracellular condensates

Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking

VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation

Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells

Antibiotic target discovery by integrated phenotypic and activity-based profiling of electrophilic fragments

Mechanisms and functions of lysosomal lipid homeostasis

Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes

Targeting biomolecular condensates: The rise of engineered chaperones

Lipid it up: Freed fats drive ferroptosis

Disrupting neuron-tumor networking connections

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