Cell Chemical Biology · Scour

An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels

Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors

Discovery of a tau-aggregate clearing compound that covalently targets P4HB

CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity

Disrupting intracellular RAGE signaling to combat pathological inflammation in disease

New twists in anti-malarial drug resistance

Organelle-ly speaking: Cracking the code of cellular clean-up

Disruption of P. falciparum amino acid transporter elevates intracellular proline and induces resistance to Prolyl-tRNA synthetase inhibitors

Valence and avidity determine the agonistic activity of anti-TNFR2 nanobody fusion proteins

Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors

CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity

Discovery of a tau-aggregate clearing compound that covalently targets P4HB

RAGE-mediated activation of the formin DIAPH1 and human macrophage inflammation are inhibited by a small molecule antagonist

Sensing within: Mitochondrial inside-out signal transduction

Organelle-ly speaking: Cracking the code of cellular clean-up

New twists in anti-malarial drug resistance

Disrupting intracellular RAGE signaling to combat pathological inflammation in disease

Pharmacologic interrogation of USP28 cellular function in p53 signaling

A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation

Disruption to the gut microbiome by non-antibiotics is linked to infection risk

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