Cell Chemical Biology · Scour

Inhibiting cancer metastasis with water-solubilized membrane receptor CXCR4QTY-Fc as a molecular trap

Engineering affinity-matured variants of an anti-polysialic acid monoclonal antibody with superior cytotoxicity-mediating potency

A method for the detection and enrichment of endogenous cereblon substrates

Robust antitumor treatment driven by lock-and-key biorecognition of dynamic cyclic diselenide-guided chiral prodrug self-assembly

RENBP inhibition amplifies metabolic glycan labeling efficiency of antigen-presenting cells in vitro and in vivo

Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers

Site-resolved assessment of targeted protein degradation

A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner

Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury

Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22

Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

Powering the powerhouse: Mitochondrial NADPH propels oxidative metabolism

Silencing stress: Structural insights into ISR termination by the SIFI ubiquitin ligase

RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition

Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma

Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer

A cationic amphiphilic drug synergizes with strobilurin fungicides to control fungal-borne plant diseases

Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation

The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels

EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses

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