Cell Chemical Biology · Scour

Charting the development and engineering of CRISPR base editors: lessons and inspirations

Flush with insight: Decoding GPCR crosstalk in the spinal defecation center

Two sides of a co(i)ndensate

Host-like conditions validate nutrient transport as an antimalarial drug target

Integrator: A guardian against RNA-induced chaos

MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA

N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4

Integrative proximal-ubiquitomics profiling for deubiquitinase substrate discovery applied to USP30

Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism

Pantothenate kinase is an effective target for antifungal therapy

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

Meet the authors: Mitchel L. Tepe and Huiqing Zhou

Impact of radiation therapy on the immunological tumor microenvironment

Microbiota mechanisms in cancer progression and therapy

Decoding the minute-by-minute GPCR interactome unveils hormone signaling gatekeepers

Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad

Meet the authors: Xing Zhang, Kyong Fam, Tingting Dai, and Howard Hang

Engineering electrogenetic interfaces for mammalian cell control

Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5

Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction

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